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Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
SS-31
COA-backed · third-party tested
Structural class
SS-31 is a tetrapeptide Szeto-Schiller compound (D-Arg-2′6′-dimethylTyr-Lys-Phe-NH₂) that selectively partitions to the inner mitochondrial membrane by binding cardiolipin.
Pathways studied
SS-31 (elamipretide) carries a net 3+ charge at physiological pH that drives electrophoretic accumulation at the negatively charged inner mitochondrial membrane (IMM). There it interacts with cardiolipin — an anionic phospholipid unique to the IMM and essential for cristae architecture and respiratory complex assembly. Cardiolipin-SS-31 binding has been studied for: stabilising cytochrome c interaction with Complex IV, improving electron transfer efficiency at Complex I and III, and reducing superoxide/H₂O₂ generation during oxidative stress conditions. The non-natural D-Arg and 2′6′-dimethylTyr residues confer protease resistance, enabling extended incubation in cell-based assay formats.
Typical research focus
Research applications centre on mitochondrial bioenergetics and cardiolipin biology. SS-31 is frequently used as a positive control in mitochondrial ROS assays, cristae remodelling studies, and ATP synthesis efficiency experiments. Its protease-resistant design makes it suitable for primary cell cultures where longer peptide incubation times are needed.
For laboratory research use only. Not for human or veterinary use, and not for human consumption. Intended for in-vitro and pre-clinical research settings only.
How to read a certificate of analysis, what purity actually measures, and how research peptides are stored and independently verified.
The questions researchers ask most.
Every batch is independently tested by Janoshik Analytical. Each product links straight to the lab's own record, so you can check the exact purity figure yourself before you buy — nothing to take on trust.
Keep vials sealed, dry, and out of direct light. Lyophilised (freeze-dried) peptides are stable at -20 °C; once reconstituted, store as noted on the product label. Full handling notes sit on every product page.
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More in the full FAQ · Rated 4.6★ on Trustpilot
Researchers who bought SS-31 also stock these.
It brings together 2 labelled variants: 10mg and 50mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.
SS-31 is generally discussed as a tetrapeptide Szeto-Schiller compound (D-Arg-2′6′-dimethylTyr-Lys-Phe-NH₂) that selectively partitions to the inner mitochondrial membrane by binding cardiolipin. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.
Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.
This page links the broader COA library when a product-specific document is not attached. Laboratories should use the published documentation set that is currently available for the listing.
No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.
