Format
Sealed research vial
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COA-backed inventory
A$269
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Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
Structural class
SNAP-8 is an octapeptide analog of the N-terminal domain of SNAP-25 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂) studied as a competitive inhibitor of SNARE complex assembly in neuroendocrine secretion assay models.
Pathways studied
SNAP-25 is a core member of the SNARE (soluble NSF attachment protein receptor) complex — alongside syntaxin-1A and VAMP-2 — that drives neurotransmitter vesicle fusion at the presynaptic membrane. SNAP-8 is a truncated octapeptide corresponding to the N-terminal region of SNAP-25 and competitively inhibits SNARE complex formation by occupying the binding interface before the full ternary complex assembles. In neuroendocrine cell models (e.g., PC12 cells or primary neuronal cultures), SNAP-8 reduces catecholamine vesicle exocytosis in a concentration-dependent manner, validated by catecholamine release assays (amperometry, ELISA). This mechanism makes SNAP-8 a research tool for studying vesicle fusion kinetics and SNARE inhibition specificity versus botulinum toxin-based SNAP-25 cleavage.
Typical research focus
SNAP-8 is frequently contrasted with botulinum neurotoxin serotype A (BoNT/A) in SNARE research because both reduce neuromuscular transmission but via mechanistically distinct routes — competitive binding versus proteolytic cleavage. This contrast is informative for assay designs examining SNARE complex reversibility and vesicle recycling.
For laboratory research use only. Not for human or veterinary use, and not for human consumption. Intended for in-vitro and pre-clinical research settings only.
How to read a certificate of analysis, what purity actually measures, and how research peptides are stored and independently verified.
The questions researchers ask most.
Every batch is independently tested by Janoshik Analytical. Each product links straight to the lab's own record, so you can check the exact purity figure yourself before you buy — nothing to take on trust.
Keep vials sealed, dry, and out of direct light. Lyophilised (freeze-dried) peptides are stable at -20 °C; once reconstituted, store as noted on the product label. Full handling notes sit on every product page.
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More in the full FAQ · Rated 4.6★ on Trustpilot
Researchers who bought SNAP-8 also stock these.
It brings together 1 labelled variant: 10mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.
SNAP-8 is generally discussed as an octapeptide analog of the N-terminal domain of SNAP-25 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂) studied as a competitive inhibitor of SNARE complex assembly in neuroendocrine secretion assay models. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.
Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.
This page links the broader COA library when a product-specific document is not attached. Laboratories should use the published documentation set that is currently available for the listing.
No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.
