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Sealed research vial
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COA-backed inventory
A$319
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Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
Structural class
PNC27 is a 32-amino acid p53-MDM2 binding domain peptide fused to an HDM-2 penetratin sequence, studied for selective pore formation in cancer cell membranes in in vitro tumour cell model assays.
Pathways studied
PNC27 is constructed by fusing residues 12–26 of the p53 transactivation domain — which binds the hydrophobic cleft of MDM2 — with a penetratin-derived membrane-active sequence. The design premise is that MDM2 overexpressed on the surface of cancer cells (but not normal cells) acts as the receptor that tethers PNC27, after which the membrane-active domain inserts into the lipid bilayer and forms a pore. This leads to selective necrotic-like cell death in MDM2-overexpressing cancer cell lines in vitro, without equivalent toxicity in MDM2-low normal cell controls. This mechanism is mechanistically distinct from canonical p53 pathway restoration approaches and positions PNC27 as a tool for studying MDM2 cell-surface expression in tumour biology models.
Typical research focus
Research panels typically pair PNC27 with MDM2-knockdown controls, MDM2-overexpressing transfectants, and p53-null cell lines to rigorously test the MDM2-surface-expression hypothesis. Its dual mechanism (MDM2 binding + membrane disruption) also makes it an informative comparator against pure MDM2 antagonists (nutlin-3a) in pathway dissection assays.
For laboratory research use only. Not for human or veterinary use, and not for human consumption. Intended for in-vitro and pre-clinical research settings only.
How to read a certificate of analysis, what purity actually measures, and how research peptides are stored and independently verified.
The questions researchers ask most.
Every batch is independently tested by Janoshik Analytical. Each product links straight to the lab's own record, so you can check the exact purity figure yourself before you buy — nothing to take on trust.
Keep vials sealed, dry, and out of direct light. Lyophilised (freeze-dried) peptides are stable at -20 °C; once reconstituted, store as noted on the product label. Full handling notes sit on every product page.
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More in the full FAQ · Rated 4.6★ on Trustpilot
Researchers who bought PNC27 also stock these.
It brings together 1 labelled variant: 5mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.
PNC27 is generally discussed as a 32-amino acid p53-MDM2 binding domain peptide fused to an HDM-2 penetratin sequence, studied for selective pore formation in cancer cell membranes in in vitro tumour cell model assays. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.
Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.
This page links the broader COA library when a product-specific document is not attached. Laboratories should use the published documentation set that is currently available for the listing.
No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.
