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Sealed research vial
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COA-backed inventory
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Third-party tested · 99%+ purity · Dispatched from Melbourne within 1 business day · 4.6★ on Trustpilot
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Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
KPV
COA-backed · third-party tested
Structural class
KPV is a C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH) — Lys-Pro-Val — studied for NF-κB pathway modulation and anti-inflammatory signalling in intestinal epithelial and immune cell assay models.
Pathways studied
KPV represents the C-terminal tridecapeptide domain of α-MSH (residues 11–13) and retains anti-inflammatory activity in cell models despite being unable to bind classical MCRs at the nanomolar concentrations that engage full-length α-MSH. Its mechanism is proposed to involve direct nuclear entry (facilitated by the Lys residue) and inhibition of NF-κB p65 nuclear translocation, thereby reducing pro-inflammatory cytokine gene transcription in a receptor-independent manner. This MCR-independent mechanism is relevant to research comparing KPV against MC1R-dependent anti-inflammatory controls and against classical NF-κB inhibitors such as IκB kinase (IKK) inhibitors.
Typical research focus
As the minimal active fragment of α-MSH, KPV provides researchers with a tool to study the structural requirements for α-MSH anti-inflammatory activity. Comparisons between the full peptide, KPV alone, and MC1R-selective antagonist combinations allow attribution of inflammatory readouts to receptor-dependent versus receptor-independent pathways.
For laboratory research use only. Not for human or veterinary use, and not for human consumption. Intended for in-vitro and pre-clinical research settings only.
How to read a certificate of analysis, what purity actually measures, and how research peptides are stored and independently verified.
The questions researchers ask most.
Every batch is independently tested by Janoshik Analytical. Each product links straight to the lab's own record, so you can check the exact purity figure yourself before you buy — nothing to take on trust.
Keep vials sealed, dry, and out of direct light. Lyophilised (freeze-dried) peptides are stable at -20 °C; once reconstituted, store as noted on the product label. Full handling notes sit on every product page.
Order by 2pm for same-day dispatch from our Melbourne warehouse, otherwise the next business day, with tracked delivery Australia-wide. No customs, no border delays — it's already in the country.
More in the full FAQ · Rated 4.6★ on Trustpilot
Researchers who bought KPV also stock these.
It brings together 1 labelled variant: 10mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.
KPV is generally discussed as a C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH) — Lys-Pro-Val — studied for NF-κB pathway modulation and anti-inflammatory signalling in intestinal epithelial and immune cell assay models. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.
Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.
This page links the broader COA library when a product-specific document is not attached. Laboratories should use the published documentation set that is currently available for the listing.
No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.
