Format
Sealed research vial
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99%+ Purity
Lab-grade supply. Limited AU stock.
A$89.99
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Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
KPV
A$89.99
KPV is a C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH) — Lys-Pro-Val — studied for NF-κB pathway modulation and anti-inflammatory signalling in intestinal epithelial and immune cell assay models.
As the minimal active fragment of α-MSH, KPV provides researchers with a tool to study the structural requirements for α-MSH anti-inflammatory activity. Comparisons between the full peptide, KPV alone, and MC1R-selective antagonist combinations allow attribution of inflammatory readouts to receptor-dependent versus receptor-independent pathways.
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In research literature, KPV is generally treated as a C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH) — Lys-Pro-Val — studied for NF-κB pathway modulation and anti-inflammatory signalling in intestinal epithelial and immune cell assay models. KPV represents the C-terminal tridecapeptide domain of α-MSH (residues 11–13) and retains anti-inflammatory activity in cell models despite being unable to bind classical MCRs at the nanomolar concentrations that engage full-length α-MSH. Its mechanism is proposed to involve direct nuclear entry (facilitated by the Lys residue) and inhibition of NF-κB p65 nuclear translocation, thereby reducing pro-inflammatory cytokine gene transcription in a receptor-independent manner. This MCR-independent mechanism is relevant to research comparing KPV against MC1R-dependent anti-inflammatory controls and against classical NF-κB inhibitors such as IκB kinase (IKK) inhibitors.
As the minimal active fragment of α-MSH, KPV provides researchers with a tool to study the structural requirements for α-MSH anti-inflammatory activity. Comparisons between the full peptide, KPV alone, and MC1R-selective antagonist combinations allow attribution of inflammatory readouts to receptor-dependent versus receptor-independent pathways. For laboratory teams, the practical emphasis is usually on sequence identity, receptor or pathway relevance where documented, and whether KPV behaves consistently across stability, purity, and analytical verification workflows. Variant labels on this page support clearer internal referencing when multiple labelled variants are under review.
Potential research applications for KPV should be framed strictly in analytical and laboratory terms. Typical reasons a team might review this product page include:
Handling decisions should always follow the vial label, internal SOPs, and any product-specific documentation. A conservative laboratory baseline for KPV is:
If a product-specific file is not attached to this listing, the wider COA library remains the correct reference point for current published documentation. The COA section is useful for confirming how the product is labelled in the catalogue, whether purity information has been published, and whether the laboratory record for the material is complete before bench use.
When teams compare KPV with TB-500, MOTS-c, and AOD-9604, COA access also helps keep comparator decisions grounded in documented material identity rather than assumption. That is especially important for research pages that combine pricing, variant selection, and analytical records on a single URL.
Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
It brings together 1 labelled variant: 10mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.
KPV is generally discussed as a C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH) — Lys-Pro-Val — studied for NF-κB pathway modulation and anti-inflammatory signalling in intestinal epithelial and immune cell assay models. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.
Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.
This page links the broader COA library when a product-specific document is not attached. Laboratories should use the published documentation set that is currently available for the listing.
No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.
