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Sealed research vial
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Certificate of Analysis
Certificate of Analysis
Verified result: Available in document
MOTS-c
COA-backed · third-party tested
Structural class
MOTS-c is a 16-amino acid mitochondria-derived peptide (MOTS-c) encoded by the 12S rRNA gene of the mitochondrial genome and studied in AMPK activation and glucose metabolism assay models.
Pathways studied
MOTS-c is generated from a short open reading frame within human mitochondrial 12S rRNA (m.1382–1429), making it one of a small class of mitochondria-derived peptides (MDPs). In cell-based assays it activates AMPK (AMP-activated protein kinase) — a master metabolic sensor — partly via disruption of the methionine-folate one-carbon cycle and consequent effects on cellular AMP:ATP ratio. AMPK activation promotes GLUT4 translocation in skeletal muscle cell models and modulates fatty acid oxidation transcriptional programs. MOTS-c also translocates to the nucleus under stress conditions and has been studied as a transcriptional regulator of ARE (antioxidant response element)-containing gene networks.
Typical research focus
Because MOTS-c originates from a mitochondrial genome open reading frame rather than a nuclear gene, it represents an unusual retrograde signalling axis from mitochondria to cytoplasm and nucleus. Research applications include mitochondrial-nuclear communication studies, AMPK pathway biology, and comparative work against synthetic AMPK activators (AICAR, metformin) in metabolic assay panels.
For laboratory research use only. Not for human or veterinary use, and not for human consumption. Intended for in-vitro and pre-clinical research settings only.
How to read a certificate of analysis, what purity actually measures, and how research peptides are stored and independently verified.
The questions researchers ask most.
Every batch is independently tested by Janoshik Analytical. Each product links straight to the lab's own record, so you can check the exact purity figure yourself before you buy — nothing to take on trust.
Keep vials sealed, dry, and out of direct light. Lyophilised (freeze-dried) peptides are stable at -20 °C; once reconstituted, store as noted on the product label. Full handling notes sit on every product page.
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Researchers who bought MOTS-c also stock these.
It brings together 4 labelled variants: 10mg, 20mg, 40mg, and 5mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.
MOTS-c is generally discussed as a 16-amino acid mitochondria-derived peptide (MOTS-c) encoded by the 12S rRNA gene of the mitochondrial genome and studied in AMPK activation and glucose metabolism assay models. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.
Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.
Yes. This listing includes access to a product-specific COA, which should be reviewed before use so purity, identity, and documentation checks are aligned with the project record.
No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.
