MOTS-c

MOTS-c is presented here as a laboratory catalogue entry for research environments that need clear identification, labelled variants, and direct access to supporting records. The current listing includes 4 labelled variants: 20mg, 40mg, 5mg, and 10mg. That structure keeps the page useful as both a procurement reference and an indexable resource covering stock visibility, pricing context, and documentation.

Within the wider Au Peptide Labs catalogue, MOTS-c sits alongside Semax, Selank, and Ipamorelin. Researchers often review neighbouring compounds before selecting a comparator or deciding which sequence belongs in a screening panel. Keeping those internal paths close to the product page improves traceability and helps laboratory buyers compare materials without relying on vague or consumer-style copy.

In research literature, MOTS-c is generally treated as a 16-amino acid mitochondria-derived peptide (MOTS-c) encoded by the 12S rRNA gene of the mitochondrial genome and studied in AMPK activation and glucose metabolism assay models. MOTS-c is generated from a short open reading frame within human mitochondrial 12S rRNA (m.1382–1429), making it one of a small class of mitochondria-derived peptides (MDPs). In cell-based assays it activates AMPK (AMP-activated protein kinase) — a master metabolic sensor — partly via disruption of the methionine-folate one-carbon cycle and consequent effects on cellular AMP:ATP ratio. AMPK activation promotes GLUT4 translocation in skeletal muscle cell models and modulates fatty acid oxidation transcriptional programs. MOTS-c also translocates to the nucleus under stress conditions and has been studied as a transcriptional regulator of ARE (antioxidant response element)-containing gene networks.

Because MOTS-c originates from a mitochondrial genome open reading frame rather than a nuclear gene, it represents an unusual retrograde signalling axis from mitochondria to cytoplasm and nucleus. Research applications include mitochondrial-nuclear communication studies, AMPK pathway biology, and comparative work against synthetic AMPK activators (AICAR, metformin) in metabolic assay panels. For laboratory teams, the practical emphasis is usually on sequence identity, receptor or pathway relevance where documented, and whether MOTS-c behaves consistently across stability, purity, and analytical verification workflows. Variant labels on this page support clearer internal referencing when multiple labelled variants are under review.

A product-specific COA is linked on this page, with purity noted as available in the document. The COA section is useful for confirming how the product is labelled in the catalogue, whether purity information has been published, and whether the laboratory record for the material is complete before bench use.

When teams compare MOTS-c with Semax, Selank, and Ipamorelin, COA access also helps keep comparator decisions grounded in documented material identity rather than assumption. That is especially important for research pages that combine pricing, variant selection, and analytical records on a single URL.