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Sealed research vial
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Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
Structural class
IGF-1 LR3 is an engineered 83-amino acid IGF-1 analog (Long-R3-IGF-1) with an Arg3 substitution and a 13-amino acid N-terminal extension that reduces insulin-like growth factor binding protein (IGFBP) affinity by approximately 500-fold.
Pathways studied
IGF-1 LR3 retains near-native binding affinity for the IGF-1 receptor (IGF-1R) — a receptor tyrosine kinase that autophosphorylates on ligand binding and recruits IRS-1 for PI3K/Akt and Grb2-SOS for MAPK/ERK activation — but bypasses IGFBP-mediated sequestration in cell culture medium. This dramatically extends its effective half-life in serum-containing assay systems relative to native IGF-1, making it the preferred choice for cell-based proliferation, differentiation, and survival assays where IGFBP-3 and other binding proteins would otherwise limit bioavailability. The Arg3 substitution specifically reduces IGFBP-3 binding without substantially altering IGF-1R kinetics.
Typical research focus
The IGFBP bypass property is both the main experimental advantage and a design consideration — cell assays using IGF-1 LR3 are not directly comparable to assays using native IGF-1 because IGFBP buffering is absent. Researchers studying the modulating role of IGFBPs often deliberately compare LR3 against native IGF-1 to attribute differences in downstream readouts to IGFBP interference.
For laboratory research use only. Not for human or veterinary use, and not for human consumption. Intended for in-vitro and pre-clinical research settings only.
How to read a certificate of analysis, what purity actually measures, and how research peptides are stored and independently verified.
The questions researchers ask most.
Every batch is independently tested by Janoshik Analytical. Each product links straight to the lab's own record, so you can check the exact purity figure yourself before you buy — nothing to take on trust.
Keep vials sealed, dry, and out of direct light. Lyophilised (freeze-dried) peptides are stable at -20 °C; once reconstituted, store as noted on the product label. Full handling notes sit on every product page.
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More in the full FAQ · Rated 4.6★ on Trustpilot
Researchers who bought IGF-1 LR3 also stock these.
It brings together 2 labelled variants: 0.1mg and 1mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.
IGF-1 LR3 is generally discussed as an engineered 83-amino acid IGF-1 analog (Long-R3-IGF-1) with an Arg3 substitution and a 13-amino acid N-terminal extension that reduces insulin-like growth factor binding protein (IGFBP) affinity by approximately 500-fold. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.
Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.
This page links the broader COA library when a product-specific document is not attached. Laboratories should use the published documentation set that is currently available for the listing.
No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.
